Dr. Gianluigi Pironti is an Assistant Professor at Karolinska Institutet, Integrated Cardio Metabolic Center (ICMC). He is leading research projects aimed to develop new therapies for cardiovascular diseases models (MI, TAC or transgenic mice) using stem cell, modified mRNA, tissue engineered heart patches introduced by Prof. Kenneth Chien, a pioneer in this field.
Dr. Pironti obtained his PhD at University of Naples Federico II (Naples, Italy) in 2012 with program in clinical pathophysiology and experimental medicine.
From 2012 until 2015 he was a post doc fellow in the laboratory of Prof. Howard Rockman at Duke University (NC/US) studying mechanism of G Protein Coupled Receptors (GPCRs) signaling in normal and failing hearts involving exosomes.
During the years spent in US he had the opportunity to work with Nobel Laureate Prof. Robert Lefkowitz, who inspired him to move and work closer to the source of Nobel prizes, at Karolinska Institutet. There, at department of Pharmacology and Physiology, he initially focused his research on cardiomyocytes' calcium signaling and contractility in pathological and physiological condition.
Dr. Pironti has more than ten years of experience in the field of translational medicine for heart failure, attested by numerous publications on peer reviewed journals, with great experience in microsurgery on animal models and characterization of physiological parameters invasively (cardiac catheterization) and non-invasively (echocardiography). He is also coordinating and conducting projects for joint collaboration with industry partners (Astra Zeneca).
Heart Failure, ModRNA, Stem cells, Cardiac Fibrosis, Ca2+ signaling, Exosomes, Echocardiography, G Protein Coupled Receptors.